About NitroMist

WHY USE NITROMIST?

The NitroMist Aerosol Delivery System

NitroMist has a unique aerosol delivery system that maintains the potency and stability of nitroglycerin for up to 36 months (or approximately 230 sprays).

Consistent Metered Dose

NitroMist features a unique delivery system. With each spray, a consistent metered dose is delivered via propellant-driven ultrafine mist. Adequate pressure must be applied to the actuator button to receive the full dose. Unit must be primed prior to initial use.

Priming NitroMist: After receiving a new prescription or refill, patients should remove the plastic cap, place forefinger on actuator button, and press 10 times. NitroMist is now primed for 6 weeks and ready to use. If not used for more than 6 weeks, the NitroMist bottle can be adequately reprimed with 2 sprays.

NitroMist Works Fast

NitroMist is rapidly absorbed to help provide fast relief.

In one study, nitroglycerin aerosol spray provided symptom relief from acute angina in 60 seconds or less in 70% of patients vs 38% for tablets (P<.001).¹*

In another large scale study of nearly 800 angina patients, nitroglycerin spray provided rapid symptom relief in most patients—regardless of age.²*^†

Get Fast Protection

NitroMist also prevents angina that is triggered by exercise. Patients treated with NitroMist significantly increased their exercise tolerence (the time it takes to experience angina symptoms while exercising).³ Patients can take NitroMist 5 to 10 minutes before engaging in activities that may trigger an attack. NitroMist can be sprayed on or under the tongue during an angina attack and is not to be inhaled.

Convenient and Reliable

The NitroMist bottle is distinct. The pocket-sized bottle provides convenience and reliability, remaining potent for up to 36 months. It requires initial priming of 10 sprays and remains adequately primed for 6 weeks. If not used within 6 weeks, NitroMist can be adequately reprimed with 2 sprays. For complete instructions, watch the How to Take NitroMist patient video by clicking the link below.

How to Take NitroMist >>

*Study was conducted with an earlier version of nitroglycerin aerosol spray containing a CFC propellant.

†65% of patients <65 experienced symptom relief in 60 seconds or less when treated with spray vs. 34% with tablets.
57% of patients ≥65experienced symptom relief in 60 seconds or less when treated with spray vs. 36% with tablets.

References: 1. Vandenburg MJ, Griffiths GK, Brandman S. Sublingual nitroglycerin or spray in the treatment of angina. Br J Clin Pract. 1986;40(12):524-527. 2. Wight LJ, Vandenburg MJ, Potter CE, et al. A large scale comparative study in general practice with nitroglycerin spray and tablet formulations in elderly patients with angina pectoris. Euro J Clin Pharmacol. 1992;42(3):341-342. 3. Data on file, 1996, Akrimax Pharmaceuticals.

Important Safety Information

Indications and Usage: NitroMist^® is a nitrate vasodilator indicated for acute relief of an attack or acute prophylaxis of angina pectoris due to coronary artery disease.

Dosage Forms and Strengths: Lingual aerosol, 400 mcg per spray is available in either 230 metered sprays or 90 metered sprays per container.

Important Safety Information: NitroMist should not be used in patients who are using phosphodiesterase type 5 inhibitors, such as those used for the treatment of erectile dysfunction, which have been shown to potentiate the hypotensive effects of organic nitrates. NitroMist should not be used in patients with severe anemia, in patients with increased intracranial pressure, and in patients with a history of hypersensitivity to this or other nitrates or nitrites. Skin reactions consistent with hypersensitivity have been observed with organic nitrates. NitroMist should be used with caution if patients have low systolic blood pressure, are undergoing diuretic therapy, or are undergoing tissue-type plasminogen activator therapy.

Co-administration of aspirin and nitroglycerin has been reported to increase nitroglycerin levels and intravenous nitroglycerin reduces the anticoagulant effect of heparin, so activated partial thromboplastin times should be monitored. Oral administration of nitroglycerin increases bioavailability of ergotamine, so concomitant use of ergotamine and related drugs should be avoided.

Excessive use may lead to the development of tolerance.

Severe hypotension, particularly with upright posture, may occur even with small doses of nitroglycerin. Hypotension induced by nitroglycerin may be accompanied by paradoxical bradycardia and increased angina pectoris. The benefits of NitroMist in patients with acute myocardial infarction or congestive heart failure have not been established. Nitrate therapy may aggravate the angina caused by hypertrophic cardiomyopathy.

Nitroglycerin produces dose-related headaches, which may be severe. Tolerance to headaches occurs. The most common adverse reactions are headache, flushing, hypotension and syncope.

Priming NitroMist: After receiving a new prescription or refill, patients should remove the plastic cap, place forefinger on actuator button, and press 10 times. NitroMist is now primed for 6 weeks and ready to use. If not used for more than 6 weeks, the NitroMist bottle can be adequately reprimed with 2 sprays.

Click here for full Prescribing Information.

You are encouraged to report negative side effects of prescription drugs to the FDA.
Visit www.FDA.gov/medwatch or call 1-800-FDA-1088.

NitroMist is a registered trademark of NovaDel Pharma Inc., used by permission.<

Click here for Patient Prescribing Information.