The most commonly reported adverse reactions were:
- Headache, which may be severe and persistent, may occur immediately after nitroglycerin use.
- Flushing, drug rash and exfoliative dermatitis have been reported in patients receiving nitrate therapy.
- Postural hypotension, as manifest by vertigo, weakness, palpitation, and other symptoms, may develop occasionally, particularly in erect, immobile patients. Marked sensitivity to the hypotensive effects of nitrates (manifested by nausea, vomiting, weakness, diaphoresis, pallor, and collapse) may occur at therapeutic doses.
- Syncope due to nitrate vasodilatation has been reported.